MDM2 regulates a variety of cellular processes through its dual protein:protein interaction and ubiquitin ligase activities.One major function of MDM2 is to bind and ubiquitinate P53, thereby regulating its proteasomal degradation.This function is Braces in turn controlled by the cell fate determinant NUMB, which binds to and inhibits MDM2 via a sh
Due to the nature of fMRI acquisition protocols, slices cannot be acquired simultaneously, and as a result, are temporally misaligned from each other.To correct from this misalignment, preprocessing pipelines often incorporate slice timing correction (STC).However, evaluating the benefits of STC is challenging because it (1) is dependent on slice a
ABSTRACT Mandacaru (Cereus jamacaru DC - Cactaceae) possesses peculiar physiological and morphological characteristics that allow it to withstand long periods of scarcity and to adapt to different environments.Several uses have also been reported for the species from the 17th century to the present day.Given this history and the importance of the u
ABSTRACT The most common lesions observed in commercial broiler farms are hock burns and pododermatitis, defined as necrotic lesions on the plantar surface of the footpads and in the hock of growing broilers, causing pain Underwear Care Bag and compromising broiler welfare.The present study aimed at identifying the risks of hock burns and pododerma